The National Highway Traffic Safety Administration estimates that proper tire inflation could help save about 49–79 lives and prevent 6,585 to 10,635 injuries per year.
(Source: National Highway Traffic Safety Administration Study on Under-Inflated Tires, August 2001)

The Rubber Manufacturer's Association estimates that 250,000 car crashes a year result from improperly inflated tires.

Keeping tires properly inflated is perhaps the most significant action a driver can take to prevent tire failure. Driving a vehicle with a significantly underinflated tire can damage the tire's structure. If a failure occurs, it is most often a blowout or a separation, both of which can be potential safety concerns.
(Source: National Highway Traffic Safety Administration Research Report to Congress on Tire Aging, August 2007)

An ExxonMobil Chemical Company study found that nitrogen gas permeates more slowly through rubber than oxygen.
(Source: ExxonMobil Chemical Company study, "Nitrogen Inflation of Tires," presented to the National Highway Traffic Safety Administration, August, 2006)

Bridgestone says that air-inflated tires lost an average of 2.7 psi per month and nitrogen-inflated tires lost an average of 0.7 psi per month.
(Source: Guy Walenga, Clemson Tire Conference, March, 2004)

Michelin supports the use of nitrogen based on its ability to better retain pressure over a period of time.
(Source: Michelin Technical Bulletin, November, 2003)

Goodyear supports the use of nitrogen as an inflation gas in all Goodyear, Dunlop, Kelly, Associate Brand and Private Brand products, based on the ability for a tire to retain pressure for a longer period of time.
(Source: Goodyear Product Service Bulletin, June 14, 2004)

Americans use about 375 million gallons of gasoline per day. That equals to
136,875,000,000 gallons per year.
(Source: www.eia.doe.gov, Energy Information Administration official energy statistics from the U.S. Government)

Every gallon of gasoline a vehicle burns puts 20 pounds of carbon dioxide into the atmosphere.
(Source: www.fueleconomy.gov, U.S. Dept. of Energy and U.S. Environmental Protection Agency)

The U.S. could save 3.7 billion gallons of gasoline per year by maintaining properly inflated tires.
(Source: U.S. Dept. of Energy)

Underinflated tires can lower gas mileage by 0.4% for every 1 psi drop in pressure of all four tires.
(Source: www.fueleconomy.gov, U.S. Dept. of Energy and U.S. Environmental Protection Agency)

You can improve your gas mileage by around 3.3% by keeping tires inflated to the proper pressure. Underinflated tires can lower gas mileage by 0.4% for every 1 psi drop in pressure of all four tires.
(Source: www.fueleconomy.gov, U.S. Dept. of Energy and U.S. Environmental Protection Agency)

Running a tire 20% underinflated—only 5–7 pounds per square inch—can increase fuel consumption by 10%.
(Source: Goodyear news release, "Near-record gas prices fuel focus on tire inflation," March 18, 2003; www.goodyear.com/media/pr/pr_2003/22655ti.html)

The Technology & Maintenance Council of the American Trucking Assoc. (TMC) says that about 90% of the tire failures causing road debris are caused by underinflation.
(Source: TMC Tire Air Pressure Study, May 2002)

When nitrogen is used as the inflation media, the change in rubber properties is significantly slowed down or even halted.
(Source: Ford nitrogen tire inflation study)